Reports

Amino Acids: Incorporation into α- and β-Chains of Hemoglobin by Normal and Thalassemic Reticulocytes

Science  23 Oct 1964:
Vol. 146, Issue 3643, pp. 530-531
DOI: 10.1126/science.146.3643.530

Abstract

After incubation of reticulocytes with radioactive amino acid, the specific activity of the β-chain of globin from the blood of patients with thalassemia was consistently lower than that of the α-chain. In subjects without this disorder, the specific activity of the β-chain was always equal to or higher than that of the α-chain.

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