Tremorine: Its Peripheral Action on Striated Muscle

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Science  06 Nov 1964:
Vol. 146, Issue 3645, pp. 765-766
DOI: 10.1126/science.146.3645.765


Tremorine, injected intraperitoneally into rats, induces the same kind of calcium release in the motor end-plates as that induced by acetylcholine-like agents. Since the same effect results even if the appropriate motor nerve has previously been transected, it is concluded that this myoneural action of Tremorine is not due to a e entral excitation but rather to a peripheral stimulatory property of the drug.