Protein Synthesis Enhanced in the Liver of Rats Force-Fed a Threonine-Devoid Diet

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Science  06 Nov 1964:
Vol. 146, Issue 3645, pp. 766-768
DOI: 10.1126/science.146.3645.766


There is enhanced incorporation of leucine-C14 into proteins in cell-free preparations from livers of young rats force-fed a threonine-devoid diet for 3 days. This increased protein synthesis in the liver is related predominantly to enhanced activity of ribosomes. The aggregates of liver ribosomes (ergosonmes or polysomes) as measured in a sucrose gradient indicated a shift from lighter toward heavier ergosomes with a decrease in monomers.