Streptomycinoid Antibiotics: Synergism by Puromycin

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Science  06 Nov 1964:
Vol. 146, Issue 3645, pp. 772-774
DOI: 10.1126/science.146.3645.772


Puromycin synergizes the lethal action of streptomycin and related antibiotics. This is interpreted to mean that puromycin action uncovers a sensitive site (or sites) on the 30S ribosome. The streptomycinoid antibiotics can then associate more readily with the ribosome and inhibit further synthesis of valid protein.