Fructose-1,6-diphosphate Requirement of Streptococcal Lactic Dehydrogenases

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Science  06 Nov 1964:
Vol. 146, Issue 3645, pp. 775-777
DOI: 10.1126/science.146.3645.775


The lactic dehydrogenase of a strain of Streptococcus bovis specifically requires fructose-1,6-diphosphate for activity. Phosphate or fructose-1-6-diphosphate prevents inactivation of the dehydrogenase, but phosphate and other compounds cannot be substituted for the fructose-1,6-diphosphate required for activity. Lactic dehydrogenases of other species of Streptococcus show a similar requirement for fructose-1,6-diphosphate.