Staphylolytic Enzyme from Chalaropsis: Mechanism of Action

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Science  06 Nov 1964:
Vol. 146, Issue 3645, pp. 781-782
DOI: 10.1126/science.146.3645.781


The staphylolytic enzyme recently isolated from cultures of a Chalaropsis species by Hash is shown to be an acetylmurainidase that cleaves all the glycosidic linkages of N-acetylmuramic acid and N,O-diacetylmuramic acid in the cell wall of Staphylococcus aureus strain Copenhagen. It is similar in specificity to the "32 enzyme" from Streptomyces albus but it differs from egg-white lysozyme whose activity is inhibited by the presence of O-acetyl groups.