Histamine: Differences in Amount Available for Release in Lungs of Guinea Pigs Susceptible and Resistant to Acute Anaphylaxis

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Science  20 Nov 1964:
Vol. 146, Issue 3647, pp. 1061-1062
DOI: 10.1126/science.146.3647.1061


Susceptibility to acute anaphylaxis in guinea pigs is related to the quantity of liberable histamine available for release in the lung. In highly suscepti-ble Hartley animals this amount can be more than 10 times greater than in the resistant strain 2. Strain 2 and Hartley guinea pigs are equally susceptible to his-tamine toxicity, and their organs fix I131-labeled antibody equally well.