Action of Erythromycin on "Protoplasts" in vivo

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Science  04 Dec 1964:
Vol. 146, Issue 3649, pp. 1299-1300
DOI: 10.1126/science.146.3649.1299


Bacteria may persist in "protoplast" form in kidneys after treatment of experimental enterococcal pyelonephritis with penicillin. Erythromycin, while ineffective against the bacterial form of infection, was able to kill "protoplasts" in vivo. This finding is consistent with the hypothesis that intact cell wall interferes with the ingress of erythromycin into the cellular area in which it acts.