Actinomycin D: An Effect on Rat Liver Homogenates Unrelated to Its Action on RNA Synthesis

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Science  04 Dec 1964:
Vol. 146, Issue 3649, pp. 1311-1313
DOI: 10.1126/science.146.3649.1311


Liver homogenates prepared from rats injected with high doses of actinomycin D show a decrease in polyribosome content and in amino acid incorporation. These effects are not observed in rat liver not subjected to homogenization and are independent of the inhibition of RNA synthesis caused by the antibiotic.