Uricase: Localization in Hepatic Microbodies

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Science  04 Dec 1964:
Vol. 146, Issue 3649, pp. 1316-1318
DOI: 10.1126/science.146.3649.1316


Microbodies of rat hepatic cells and hepatomas contain a crystalloid with the same structural characteristics as crystals of purified uricase, when viewed by electron microscopy. We conclude that crystalline uricase is located within hepatic microbodies.