Paradoxical Phase of Sleep: Its Artificial Induction in the Cat by Sodium Butyrate

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Science  04 Dec 1964:
Vol. 146, Issue 3649, pp. 1328-1329
DOI: 10.1126/science.146.3649.1328


In intact cats and cats with the mesencephalon transected the intravenous administration of sodium butyrate and related compounds (0.3 to 3 millimoles per kilogram) induced the so-called paradoxical phase of the sleep, as indicated by electroencephalograms, electromyograms, heart rate, respiration, and eye movement. This phase appeared after a 3- to 5-minute period of sleep characterized by slow waves, and continued for 4 to 15 minutes.