Endogenous Pyrogen Release from Rabbit Blood Cells Incubated in vitro with Parainfluenza Virus

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Science  11 Dec 1964:
Vol. 146, Issue 3650, pp. 1469-1470
DOI: 10.1126/science.146.3650.1469


Rabbit blood cells incubated in vitro with purified parainfluenza-5 virus (DA strain) released a rapidly acting pyrogen. Spleen and lymph node cells were inactive. The pyrogen resembled in behavior a pyrogen extracted from granulocytic exudates. Similar cells in the blood are believed to be activated by virus in vivo to produce the circulating endogenous pyrogen that mediates virus-induced fever.