Protein Structure Relationships Revealed by Mutational Analysis

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Science  18 Dec 1964:
Vol. 146, Issue 3651, pp. 1593-1594
DOI: 10.1126/science.146.3651.1593


Studies of tryptophan synthetase A-protein mutants have shown a structural relationship between the positions of amino acid changes associated with forward mutations and second-site reverse mutations.