Reovirus Hemagglutination: Inhibition by N-Acetyl-D-glucosamine

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Science  22 Jan 1965:
Vol. 147, Issue 3656, pp. 404-405
DOI: 10.1126/science.147.3656.404


Purified reoviruses types 1, 2, and 3 were specifically inhibited in their hemagglutination of human erythrocytes by 250 micromoles or more of N-acetyl-D-glucosamine but not by over 20 other sugars tested. N-acetyl-D-glucosamine inhibited reovirus hemaglutination by binding to capsid virus; it did not attach to the erythrocytes. It is possible that reovirus hemagglutination involves union between N-acetyl-D-glucosamine on the surface of the red cell and the glycoprotein of the virus coat.