Moloney Virus-Induced Leukemias of Mice: Measurement in vitro of Specific Antigen

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Science  29 Jan 1965:
Vol. 147, Issue 3657, pp. 506-507
DOI: 10.1126/science.147.3657.506


A modified test for cytotoxic antibody may be used to measure antibody directed against the tumor-specific antigen of leukemias of mice induced by Moloney virus; cell death is detected by liberation of 51Cr. An inhibition test based on this technique permits accurate measurement of tumor-specific antigen in cells and subcellular fractions.