Tumor and Virus Antigens of Simian Virus 40: Differential Inhibition of Synthesis by Cytosine Arabinoside

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Science  05 Feb 1965:
Vol. 147, Issue 3658, pp. 625-627
DOI: 10.1126/science.147.3658.625


Cells infected with the papovavirus SV40 not only synthesize viral antigen but also synthesize the specific nonviral antigen found in SV40-induced tumors. In the presence of the DNA antagonist cytosine arabinoside, infected cells fail to make viral antigen but still synthesize the tumor antigen. Iododeoxyuridine does not inhibit the synthesis either of tumor or of virus antigen but does prevent the development of infectious virus.