5-Hydroxytryptophan Decarboxylase in Rat Brain: Effect of Hypothalamic Lesions

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Science  19 Feb 1965:
Vol. 147, Issue 3660, pp. 887-888
DOI: 10.1126/science.147.3660.887


Section of the medial forebrain bundle within the lateral hypothalamus of the rat reduces the serotonin content and the 5-hydroxytryptophan decarboxylase activity in the brain. The integrity of this fiber tract appears necessary for the maintenance of normal concentrations of the amine and enzyme in the telencephalon.