Carcinogenic Aromatic Hydrocarbons: Special Vulnerability of Rats

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Science  05 Mar 1965:
Vol. 147, Issue 3662, pp. 1153-1154
DOI: 10.1126/science.147.3662.1153


Compared with other species, the rat is unusually vulnerable to polynuclear aromatic hydrocarbons. In the rat, relatively small amounts of carcinogenic aromatics (i) profoundly depress incorporation of thymidine in DNA, (ii) greatly induce menadione reductase in liver, and (iii) then kill the rat.