Anaphylactic Reaction of Denervated Skeletal Muscle in the Guinea Pig

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Science  05 Mar 1965:
Vol. 147, Issue 3662, pp. 1155-1156
DOI: 10.1126/science.147.3662.1155


Muscle strips taken from chronically denervated hemidiaphragms of guinea pigs immunized to ovalbumin react in vitro to the administration of small amounts of this protein with a contraction similar to that of visceral muscle in the Schultz-Dale reaction. A sustained shortening is produced by histamine on denervated diaphragmatic muscle from both sensitized and nonsensitized guinea pigs.