Immunoglobulin Structure: Amino- and Carboxyl-Terminal Peptides of Type I Bence Jones Proteins

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Science  12 Mar 1965:
Vol. 147, Issue 3663, pp. 1304-1305
DOI: 10.1126/science.147.3663.1304


Analysis of the amino acid sequence in Bence Jones proteins permits study of the structure of L-chains of normal immunoglobulins. An amino-terminal octadecapeptide containing the sole methionine residue occurs in many but not all immunoglobulins of antigenic type I. The carboxyl-terminal octapeptide appears invariant in type I proteins and ends in cysteine, which may have a cross-linking function.