Bursa of Fabricius in Chickens: Possible Humoral Factor

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Science  12 Mar 1965:
Vol. 147, Issue 3663, pp. 1307-1308
DOI: 10.1126/science.147.3663.1307


Chicks bursectomized by testosterone injection on the 5th day of incubation showed a marked inability to produce antibodies to Salmonella typhimurium. When portions of the bursa of Fabricius were enclosed in cell-impermeable Millipore diffusion chambers and implanted subcutaneously or intraperitoneally, the antibody-producing capacity of these animals was restored. Evidence strongly suggests that the bursa of Fabricius elaborates a non-cellular agent capable of restoring immunologic reactivity in bursectomized chicks.