Uracil Mustard: A Potent Inducer of Lung Tumors in Mice

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Science  19 Mar 1965:
Vol. 147, Issue 3664, pp. 1443-1445
DOI: 10.1126/science.147.3664.1443


Uracil mustard, injected intraperitoneally, increased the incidence and average number of pulmonary tumors in A/J mice. In comparison to a typical alkylating agent, nitrogen mustard, or to urethan, uracil mustard (on a molar basis) was considerably more carcinogenic.