Bipolarity of Information Transfer from the Salmonella typhimurium Chromosome

Science  19 Mar 1965:
Vol. 147, Issue 3664, pp. 1456-1458
DOI: 10.1126/science.147.3664.1456


Apparently the leucine and tryptophan gene clusters are polarized in opposite directions on the Salmonella chromosome. Either the direction of polarity is independently determined for each operon or the bacterial chromosome may consist of more than one multi-operon unit of DNA, each such unit determining the direction of polarity of its constituent genes. Each hypothesis results in a different prediction concerning the distribution of operon polarity directions on the chromosome and the functional status of chromosomal inversions.