Cystinuria: Effect of D-Penicillamine on Plasma and Urinary Cystine Concentrations

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Science  19 Mar 1965:
Vol. 147, Issue 3664, pp. 1459-1460
DOI: 10.1126/science.147.3664.1459


Administration of penicillamine reduced the concentration of cystine in the plasma and urine of patients with cystinuria; renal clearance of cystine, lysine, and arginine remained unchanged. Cysteine-penicillamine disulfide and penicillamine disulfide were detected in the plasma.