Tricarboxylic Acid Cycle Mutants in Saccharomyces: Comparison of Independently Derived Mutants

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Science  26 Mar 1965:
Vol. 147, Issue 3665, pp. 1590
DOI: 10.1126/science.147.3665.1590


A yeast mutant independently isolated as a glutamate auxotroph (glt2-1) was similar to the glt1-1 mutant in exhibiting a blocked tricarboxylic acid cycle due to the lack of aconitate hydratase. The new mutant differed by exhibiting blocks in lysine and cytochrome biosynthesis which segregated together with the glutamate requirement.