Involvement of Thymus in Immune Response of Rabbits to Somatic Polysaccharides of Gram-Negative Bacteria

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Science  26 Mar 1965:
Vol. 147, Issue 3665, pp. 1591-1592
DOI: 10.1126/science.147.3665.1591


Plaque-forming cells elaborating antibody specific for Salmonella enteritidis somatic antigen have been demonstrated in the thymus of rabbits 5 days after a single systemic injection of a minute amount of this bacterial polysaccharide. A marked decrease in organ weight and loss of thymic cellularity was also seen, and was most pronounced at the time when antibody-forming cells made their appearance.