Indole Compounds: Isolation from Pineal Tissue

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Science  02 Apr 1965:
Vol. 148, Issue 3666, pp. 102-103
DOI: 10.1126/science.148.3666.102


Five indole compounds have been isolated from bovine pineal tissue and characterized as 5-methoxytryptophol, N-acetyl-5-methoxytryptamine (melatonin), 5-hydroxytryptophol, 5-methoxyindole-3-acetic acid, and 5-hydroxyindole-3-acetic acid. Pineal hydroxyindole-O-methyltransferase, with S-adenosylmethionine, converts 5-hydroxytryptophol to 5-methoxytryptophol.