Cerebellar Disease in Cats Induced by Inoculation of Rat Virus

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Science  09 Apr 1965:
Vol. 148, Issue 3667, pp. 244-246
DOI: 10.1126/science.148.3667.244


Rat virus selectively destroys the external germinal layer of the cerebellar cortex when inoculated intracerebrally into newborn cats. The lesions are marked by numerous intranuclear inclusion bodies and a rise of virus titers. These effects suggest that the spontaneous ataxia of cats which is accompanied by cerebellar hypoplasia, may be of viral origin.