Hybrid Antibody Molecules with Allotypically Different L-Polypeptide Chains

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Science  16 Apr 1965:
Vol. 148, Issue 3668, pp. 383-385
DOI: 10.1126/science.148.3668.383


Isolated L-chains with either the A4 or the A5 allotypic markers from rabbit antibodies to 2,4-dinitrophenyl determinant recombine at random with antibody H-chains in the presence or absence of the hapten to produce hybrid precipitating antibody molecules.