Linkage in Control of Allotypic Specificities on Two Different γG-Immunoglobulins

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Science  30 Apr 1965:
Vol. 148, Issue 3670, pp. 640-642
DOI: 10.1126/science.148.3670.640


Allotypic specificities were identified on two different myeloma proteins and the corresponding normal γG-immunoglobulins of BALB/c mice. When the sera of F2 progeny from a cross between BALB/c mice having the a1 allotype and AL mice having the a4 allotype were tested for these specificities, it was found that the two allotypic specificities of the BALB/c mice were either both present (87 mice) or both absent (36 mice), an indication of linkage in their genetic control.