5-Hydroxytryptamine in Single Neoplastic Mast Cells: A Microscopic Spectrofluorometric Study

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Science  30 Apr 1965:
Vol. 148, Issue 3670, pp. 642-644
DOI: 10.1126/science.148.3670.642


5-Hydroxytryptamine, catecholamines, and histamine in mast cells can be distinguished by fluorescence microscopy. Microscopic spectrofluorometry can be used to estimate 5-hydroxytryptamine in single neoplastic mast cells grown in vitro, and to study the effect of reserpine on these cells.