Reports

Hereditary Angioneurotic Edema: Two Genetic Variants

Science  14 May 1965:
Vol. 148, Issue 3672, pp. 957-958
DOI: 10.1126/science.148.3672.957

Abstract

Serums of patients with hereditary angioneurotic edema lack inhibitory activity against the esterase derived from the first component of complement. In one group of patients this lack appears to result from failure to synthesize the esterase inhibitor of the first component of complement, whereas in another group of patients an abnormal, nonfunctional protein is synthesized.