Autosomally Determined Polymorphism of Glucose-6-Phosphate Dehydrogenase in Peromyscus

Science  21 May 1965:
Vol. 148, Issue 3673, pp. 1099-1100
DOI: 10.1126/science.148.3673.1099


Glucose-6-phosphate dehydrogenase commonly occurs in at least two forms in most tissues of the deer mouse, Peromyscus maniculatus, as demonstrated by starch-gel electrophoresis. An autosomally determined genetic polymorphism in one of the enzymes was discovered. A hybrid molecule occurs in the heterozygote; this suggests a dimeric structure of this enzyme.