Polymorphism of Human Lactate Dehydrogenase Isozymes

Science  21 May 1965:
Vol. 148, Issue 3673, pp. 1103-1105
DOI: 10.1126/science.148.3673.1103


Of 1200 individuals screened, four had variant erythrocyte lactate dehydrogenases. Three of these, identical electrophoretically to the Mem-1 described by Kraus and Neely, were heterozygous variants involving the a-locus. The fourth, involving the b-locus, appears to be the first example in man of a homozygous variant.