Neural Stage of Adaptation between the Receptors and Inner Nuclear Layer of Monkey Retina

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Science  21 May 1965:
Vol. 148, Issue 3673, pp. 1113-1115
DOI: 10.1126/science.148.3673.1113


The local electroretinogram of the monkey retina is recorded by intraretinal microelectrodes. Observations of the late receptor potential, isolated by selective clamping of the retinal circulation, show that when the retina is light-adapted by repetitive stimulation, the amplitude of the receptor potential is only slightly reduced over a slow time course. The reduction in amplitude of the b-wave is much greater and occurs much more rapidly. Thus there is a neural stage of adaptation between the late receptor potential and the generation of the b-wave by cells of the inner nuclear layer.