Quinine-Resistant Plasmodium berghei in Mice

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Science  28 May 1965:
Vol. 148, Issue 3674, pp. 1240-1241
DOI: 10.1126/science.148.3674.1240


During induction of chloroquine resistance, Plasmodium berghei developed resistance to quinine administered in doses near the maximum amounts tolerated by mice. Resistant parasites did not form malarial pigment. Normal sensitivity to both quinine and chloroquine returned and pigment formation resumed during serial passage of the parasites through untreated mice.