Facilitation: Electrical Response Enhanced by Conditional Excitation of Cerebral Cortex

Science  28 May 1965:
Vol. 148, Issue 3674, pp. 1246-1248
DOI: 10.1126/science.148.3674.1246


Cats were conditioned to give a foot flexion in response to stimulation of the brain through implanted electrodes. The evoked electrical activity of an extracallosal interhemispheric pathway was much greater in the repeatedly stimulated direction than in the unstimulated direction in the brain. No difference in the two directions was observed in control animals that did not receive the unconditional foot shock.