Retrograde Amnesia from Electroconvulsive Shock in a One-Trial Appetitive Learning Task

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Science  28 May 1965:
Vol. 148, Issue 3674, pp. 1248-1250
DOI: 10.1126/science.148.3674.1248


Rats deprived of water were placed, for 4-minute sessions, into a chamber containing a hole in one wall. After several sessions the number of times these rats explored the hole markedly decreased. Rats given access to water at the hole for a brief period explored the hole more frequently than controls, when they were tested later. This increase in hole explorations was abolished when the water reinforcement was followed by electro-convulsive shock but not when followed by foot shock.