Specificity of Macroglobulin Antibody Synthesized by the Normal Human Fetus

Science  18 Jun 1965:
Vol. 148, Issue 3677, pp. 1591-1592
DOI: 10.1126/science.148.3677.1591


The umbilical cord blood of 47 out of 54 normal human infants contains hemagglutinating activity directed toward cells coated with a type-L Bence-Jones protein. This hemagglutinating material, in some instances, is present in cord blood in the absence of such activity in the maternal blood. Ultracentrifugation of cord serum in a sucrose gradient shows that the activity is associated with the macroglobulin fractions.