Phenotypic Alterations in Adrenal Tumor Cultures

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Science  25 Jun 1965:
Vol. 148, Issue 3678, pp. 1733-1734
DOI: 10.1126/science.148.3678.1733


Adrenal tumor cells in culture gradually develop a requirement for glutamine and serum albumin in order to produce steroids in response to adrenocorticotropic hormone. Glutamine acts simply as a precursor for a protein or proteins whose synthesis is required for the response to the hormone. Albumin apparently binds steroid hormone products that otherwise would inhibit further biosynthesis of steroids.