Degeneration of the Eyes of Tyrosine-Deficient Chick Embryos

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Science  25 Jun 1965:
Vol. 148, Issue 3678, pp. 1743-1745
DOI: 10.1126/science.148.3678.1743


Subjecting 4-day-old chick embryos to a yolk-sac perfusion medium lacking tyrosine resulted in arrest of retinal pigmentation and in degeneration of the neural retina. Phenylaldnine was ineffective in replacing tyrosine. Possibly retinal tyrosinase played a part in initiating the degenerative changes.