Radiation Resistance in Lipovirus-Altered Human Cells

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Science  25 Jun 1965:
Vol. 148, Issue 3678, pp. 1746-1747
DOI: 10.1126/science.148.3678.1746


Human cells altered by infection with the "lipovirus," a transmissible cytopathic agent, are highly resistant to ionizing radiation. Whereas about 500 roentgens will inhibit cell multiplication in normal cells, more than 500,000 roentgens are required to produce a similar effect in the altered cells. This gross change in cellular radiosensitivity may provide a useful system for studying in vitro the mechanisms of inhibition of cell division by radiation.