Abrogation of Allogeneic Inhibition by Cortisone

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Science  02 Jul 1965:
Vol. 149, Issue 3679, pp. 82-84
DOI: 10.1126/science.149.3679.82


Tumor cells from homozygous mice grow better upon transplanation to syngeneic mice than to F1 hybrids between the tumor strain and a foreign strain. The inhibition of cell growth in the hybrids (called allogeneic inhibition), which is detected by tumor transplantation into mice, cotuld be abrogated by treatment of the recipient mice with cortisone acetate. Cortisone also abolished allogeneic inhibition in vitro; abolition was detected by treating tumor cultures with cell extracts containing foreign isoantigens of the H-2 type.