Actinomycin D Inhibition of Vitamin D Action

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Science  09 Jul 1965:
Vol. 149, Issue 3680, pp. 182-184
DOI: 10.1126/science.149.3680.182

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Injection of actinomycin D into rats completely prevents both the rise in serum calcium normally induced by vitamin D and the increased transport of calcium by everted intestinal sacs. Injection of excess parathyroid hormone did not alter this result; this eliminates the possibility that the inhibition of vitamin action was due to blocked hormone synthesis. As a result of these findings, a hypothesis concerning the mechanism of action of vitamin D is presented.