Suppression in vitro: Identification of a Serine-sRNA as a "Nonsense" Suppressor

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Science  23 Jul 1965:
Vol. 149, Issue 3682, pp. 417-422
DOI: 10.1126/science.149.3682.417


In a cell-free system, with RNA from a suppressible mutant of bacteriophage R17 as messenger,. no functional coat protein of the bacteriophage is synthesized unless serine-accepting soluble RNA from the suppressor strain, Escherichia coli S26RIE, is present.