Spermidine in Regenerating Liver: Relation to Rapid Synthesis of Ribonucleic Acid

Science  23 Jul 1965:
Vol. 149, Issue 3682, pp. 428-429
DOI: 10.1126/science.149.3682.428


The spermidine in rat liver increases after partial hepatectomy, and the rate of polyamine accumulation closely approximates the increased rate of synthesis of RNA in regenerating liver. The uptake by the liver of intravenously injected putrescine and the biosynthesis of spermidine are accelerated within 2 hours after the operation. The uptake of spermidine also increases during early regeneration.