Pseudouridine Formation: Evidence for RNA as an Intermediate

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Science  23 Jul 1965:
Vol. 149, Issue 3682, pp. 429-431
DOI: 10.1126/science.149.3682.429


Experiments with intact or lysed spheroplasts from Escherichia coli indicate that conditions which impair the DNA-directed synthesis of RNA, also prevent formation of pseudouridine. Studies with uridine-labeled RNA support the concept that RNA may be a direct intermediate for pseudouridine synthesis.