Square Root Variations of Reciprocal Graphing of Enzyme Kinetic Data

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Science  23 Jul 1965:
Vol. 149, Issue 3682, pp. 447-448
DOI: 10.1126/science.149.3682.447


A variation of the Lineweaver and Burk graph, in which the reciprocal of the square root of the initial reaction velocity is plotted as a function of the reciprocal of the substrate concentration, has been described in the literature and has subsequently been used as the basis of proposals of reaction mechanisms. The utility of this treatment of enzyme kinetic data is examined and has been found to be limited.