Adaptive Enzyme Synthesis: Its Inhibition as a Possible Analogue of Immunological Tolerance

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Science  30 Jul 1965:
Vol. 149, Issue 3683, pp. 548-550
DOI: 10.1126/science.149.3683.548


Substrate induction of tryptophan pyrrolase in the liver of rats is inhibited by prior treatment of very young rats with tryptophan. This inhibition seems analogous to immunological tolerance, which can be produced by prior treatment with the antigen. The findings prowide support for an analogy between mechanisms of adaptive enzyme synthesis and those involved in adaptive immunity.