Growth of Mouse Mammary Glands in vivo after Monolayer Culture

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Science  06 Aug 1965:
Vol. 149, Issue 3684, pp. 634-636
DOI: 10.1126/science.149.3684.634


Mouse mammary tissue grown in primary cell culture did not display specialized characteristics of the parent tissue. When implanted into gland-free mammary fat pads, not only did some of these cultured cells grow and produce normal mammary outgrowths, but some of the outgrowths formed glands which displayed a variety of culture-induced abnormalities.